Enlow R W, Bias W B, Arnett F C
Arthritis Rheum. 1980 Dec;23(12):1359-65. doi: 10.1002/art.1780231205.
Of 12 patients with inflammatory bowel disease (IBD) and ankylosing spondylitis (AS) or sacroiliitis (SI), only 4 (32%) had HLA-B27. Family studies revealed 3 B27-negative relatives with AS, 1 with SI, 1 with SI and IBD, and 1 with IBD alone. HLA haplotypes did not segregate with disease. These data suggest a non-HLA linked genetic predisposition to IBD which also confers susceptibility to spondylitis, even in the absence of expression of bowel disease.
在12例患有炎症性肠病（IBD）并伴有强直性脊柱炎（AS）或骶髂关节炎（SI）的患者中，只有4例（32%）携带HLA - B27。家族研究发现3名HLA - B27阴性的亲属患有AS，1名患有SI，1名患有SI和IBD，还有1名仅患有IBD。HLA单倍型与疾病无关联。这些数据表明，IBD存在一种与HLA无关的遗传易感性，这种易感性即使在肠道疾病未表现时也会使人易患脊柱炎。
