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伊朗蛇类毒液的产量和致死性差异。

Variation in yield and lethality of venoms from Iranian snakes.

作者信息

Latifi M

出版信息

Toxicon. 1984;22(3):373-80. doi: 10.1016/0041-0101(84)90081-3.

DOI:10.1016/0041-0101(84)90081-3
PMID:6474490
Abstract

The dangerous venomous terrestrial snakes of Iran belong to three groups: the Elapidae (cobras); the Viperinae (true vipers); the Crotalinae (pit vipers). Geographical distribution of each species was determined. Studies on the venoms extracted from the following Iranian snakes, Oxus cobra, Naja naja oxiana, Levantine viper (Afyi), Vipera lebetina, Carpet viper, Echis carinatus, Persian horned viper, Pseudocerastes persicus, Latifii viper, Vipera latifii, Mountain viper, Vipera xanthina and Caucasus pit viper (Agkistrodon halys), indicated that the yield of venom varies in each species. Venoms were compared for their lethality (i.v. LD50 in mice) and their rate of production. The antigenic components of the venoms were compared with their antisera by gel diffusion tests. To obtain the best results from antivenom treatment, the serum should be made against the venom of the local population of snakes or, at least, the commercial antivenom should be controlled for potency by testing with local reference venom.

摘要

伊朗危险的有毒陆生蛇类分为三类

眼镜蛇科(眼镜蛇);蝰蛇亚科(真正的蝰蛇);蝮蛇亚科(蝮蛇)。确定了每个物种的地理分布。对从以下伊朗蛇类提取的毒液进行了研究,包括中亚眼镜蛇、印度眼镜蛇中亚亚种、黎凡特蝰蛇(阿菲蝰蛇)、草原蝰、锯鳞蝰、波斯角蝰、拉蒂菲蝰、山蝰、黄链蛇蝰和高加索蝮蛇(白眉蝮),结果表明每个物种的毒液产量各不相同。比较了毒液的致死性(小鼠静脉注射半数致死量)及其产生速率。通过凝胶扩散试验比较了毒液与其抗血清的抗原成分。为了从抗蛇毒血清治疗中获得最佳效果,血清应针对当地蛇类种群的毒液制备,或者至少应通过用当地参考毒液进行测试来控制商业抗蛇毒血清的效力。

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