Kurath P, Rosenbrook W, Dunnigan D A, McAlpine J B, Egan R S, Stanaszek R S, Cirovic M, Mueller S L, Washburn W H
J Antibiot (Tokyo). 1984 Oct;37(10):1130-43. doi: 10.7164/antibiotics.37.1130.
The structure of lysinomicin, a new aminocyclitol antibiotic, was established as 3-epi-2'-N-(L-beta-lysyl)-4',5'-didehydro-6'-de-C-methylfortimi cin B (1) on the basis of spectral evidence and chemical degradation of the antibiotic. In the course of the degradation of 1, three additional compounds with interesting biological properties were obtained: 3-epi-2'-N-(L-beta-lysyl)-6'-de-C-methylfortimicin B (4), 3-epi-4',5'-didehydro-6'-de-C-methylfortimicin B (6) and 3-epi-6'-de-C-methylfortimicin B (7).
新型氨基环醇抗生素lysinoicin的结构经光谱证据及该抗生素的化学降解确定为3-表-2'-N-(L-β-赖氨酰)-4',5'-二脱氢-6'-去-C-甲基福提霉素B(1)。在1的降解过程中，获得了另外三种具有有趣生物学特性的化合物：3-表-2'-N-(L-β-赖氨酰)-6'-去-C-甲基福提霉素B(4)、3-表-4',5'-二脱氢-6'-去-C-甲基福提霉素B(6)和3-表-6'-去-C-甲基福提霉素B(7)。
