Konishi M, Sugawara K, Hanada M, Tomita K, Tomatsu K, Miyaki T, Kawaguchi H, Buck R E, More C, Rossomano V Z
J Antibiot (Tokyo). 1984 Sep;37(9):949-57. doi: 10.7164/antibiotics.37.949.
Empedopeptin is a new antibiotic produced by empedobacter haloabium nov. sp. (ATCC 31962). It is a water-soluble depsipeptide antibiotic containing eight amino acid residues and a C14-fatty acid moiety in the molecule. Although structurally unrelated, empedopeptin and vancomycin have similar antimicrobial spectra against aerobic and anaerobic Gram-positive bacteria including antibiotic-resistant strains. Empedopeptin is highly active in vivo in mice against systemic infections of Staphylococcus aureus, Streptococcus pyogenes and Clostridium perfringens. Empedopeptin is not absorbed orally.
恩培多肽是由嗜盐栖居杆菌新种（ATCC 31962）产生的一种新型抗生素。它是一种水溶性缩肽抗生素，分子中含有八个氨基酸残基和一个C14脂肪酸部分。尽管恩培多肽和万古霉素在结构上不相关，但它们对需氧和厌氧革兰氏阳性菌（包括耐药菌株）具有相似的抗菌谱。恩培多肽在小鼠体内对金黄色葡萄球菌、化脓性链球菌和产气荚膜梭菌的全身感染具有高度活性。恩培多肽口服不吸收。
