Winchurch R A, Thomas D J, Adler W H, Lindsay T J
J Immunol. 1984 Aug;133(2):569-71.
The in vitro production of antibody to T-dependent antigens is depressed as a function of age. The addition of supplemental zinc to cultures of cells from young adult, middle-aged, and immunodepressed-aged mice enhances antibody production. The responses of young mice are enhanced 30 to 40%, but the responses in cultures from aged mice are increased 5- to 12-fold and the maximum response achieved is often equivalent to that of young, fully competent mice. The addition of zinc at varying times during the culture period suggests that zinc affects early events in the activation of antibody-forming cells.
针对T细胞依赖性抗原的抗体体外产生量会随着年龄增长而降低。向来自年轻成年小鼠、中年小鼠和免疫功能低下老年小鼠的细胞培养物中添加补充锌可增强抗体产生。年轻小鼠的反应增强了30%至40%，但老年小鼠培养物中的反应增加了5至12倍，并且达到的最大反应通常与年轻、免疫功能完全正常的小鼠相当。在培养期间的不同时间添加锌表明，锌会影响抗体形成细胞激活过程中的早期事件。
