Khan J A, Hoover D, Ide C H
Am J Ophthalmol. 1984 Nov;98(5):562-5. doi: 10.1016/0002-9394(84)90241-1.
Blepharoconjunctivitis caused by methicillin-resistant strains of Staphylococcus epidermidis occurred in two hospitalized patients, a 74-year-old man and a 19-year-old man. Both strains were resistant to multiple courses of topical antibiotic therapy. Successful treatment in both cases depended upon antibiotic sensitivity testing. These methicillin-resistant strains of S. epidermidis, like methicillin-resistant strains of Staphylococcus aureus, demonstrated almost complete cross-resistance to cephalosporins despite apparent sensitivity on Kirby-Bauer disk sensitivity testing. Topical vancomycin was curative in one case. In the other case, treatment with topical gentamicin, intravenous cefoperazone, and oral rifampin led to resolution of the symptoms.
两名住院患者，一名74岁男性和一名19岁男性，发生了由耐甲氧西林表皮葡萄球菌菌株引起的睑结膜炎。两种菌株均对多疗程局部抗生素治疗耐药。两例患者的成功治疗均依赖于抗生素敏感性试验。这些耐甲氧西林表皮葡萄球菌菌株，与耐甲氧西林金黄色葡萄球菌菌株一样，尽管在Kirby-Bauer纸片扩散法药敏试验中显示出明显的敏感性，但对头孢菌素几乎完全交叉耐药。局部应用万古霉素在一例中治愈。在另一例中，局部应用庆大霉素、静脉注射头孢哌酮和口服利福平治疗后症状缓解。
