Rückert K, Klink E, Klöppel G
Langenbecks Arch Chir. 1979 Aug;348(4):261-8. doi: 10.1007/BF01317612.
The pancreatic carcinogen DHPN (dihydroxypropylnitrosamin) was administered to Syrian golden hamsters. By intragastric administration more pancreatic carcinomas in the head of the gland were induced than by subcutaneous injections. After choledochojejunostomy the incidence of carcinomas was only 5--7% and the lesions were similar in multiplicity and distribution without relationship to the way of administration. The importance of biliary reflux in pancreatic tumor induction is discussed and the role of bile concerning the preferred localisation of the tumors in the head of the pancreas.
将胰腺致癌物二羟丙基亚硝胺（DHPN）给予叙利亚金黄地鼠。通过胃内给药诱导出的胰腺头部癌比皮下注射更多。胆总管空肠吻合术后，癌的发生率仅为5 - 7%，病变在数量和分布上相似，与给药方式无关。讨论了胆汁反流在胰腺肿瘤诱导中的重要性以及胆汁在胰腺头部肿瘤优先定位方面的作用。
