van Straaten F, Müller R, Curran T, Van Beveren C, Verma I M
Proc Natl Acad Sci U S A. 1983 Jun;80(11):3183-7. doi: 10.1073/pnas.80.11.3183.
The complete nucleotide sequence of the c-fos(human) gene, the human cellular homolog of the oncogene (v-fos) of Finkel-Biskis-Jinkins murine osteosarcoma virus, has been determined. The c-fos(human) gene contains four discontinuous regions when compared with the v-fos gene. Three of the discontinuities are flanked by sequences characteristic of introns, while the fourth discontinuity is due to a deletion of 104 base pairs in the v-fos gene. As a consequence of the deletion, the predicted c-fos(human) and v-fos gene products differ at their carboxyl termini. Transcripts of 2.2 kilobases from the c-fos(human) gene have been identified in human cells. The sizes of these transcripts are in close agreement with the size expected from the nucleotide sequence after removal of introns.
已确定了c-fos（人类）基因的完整核苷酸序列，该基因是Finkel-Biskis-Jinkins小鼠骨肉瘤病毒癌基因（v-fos）的人类细胞同源物。与v-fos基因相比，c-fos（人类）基因包含四个不连续区域。其中三个不连续区域侧翼为内含子特征性序列，而第四个不连续区域是由于v-fos基因中缺失了104个碱基对。由于该缺失，预测的c-fos（人类）和v-fos基因产物在其羧基末端有所不同。已在人类细胞中鉴定出c-fos（人类）基因2.2千碱基的转录本。这些转录本的大小与去除内含子后的核苷酸序列预期大小密切相符。
