Rose A M, Baillie D L, Curran J
Mol Gen Genet. 1984;195(1-2):52-6. doi: 10.1007/BF00332723.
In this paper we describe the meiotic pairing behavior of two free duplications in Caenorhabditis elegans. sDp1 is a duplication of approximately 30 map units of the right portion of linkage group I including unc-74 to unc-54. This duplication pairs, recombines, and apparently segregates from one of the normal homologues. A second duplication, sDp2, is a duplication of approximately 15 map units of the left portion of the linkage group. sDp2 was not observed to recombine with the normal homologue but did suppress exchange between the two normal homologues in a sDp2/ ++/ dpy-5 unc-35 heterozygote. Although a number of free duplications have been described previously in Caenorhabditis elegans, none of these have been shown to pair with normal homologues. The meiotic behavior of the duplications described in this paper can be understood assuming the existence in C. elegans chromosomes of pairing sites of the type described in D. melanogaster chromosomes (I. Sandler 1956; Hawley 1980).
在本文中，我们描述了秀丽隐杆线虫中两个游离重复片段的减数分裂配对行为。sDp1是连锁群I右部约30个图距单位的重复片段，包括从unc-74到unc-54。这个重复片段能配对、重组，并且明显地从一个正常同源染色体上分离。第二个重复片段sDp2是连锁群左部约15个图距单位的重复片段。未观察到sDp2与正常同源染色体发生重组，但在sDp2/++/dpy-5 unc-35杂合子中，它确实抑制了两个正常同源染色体之间的交换。虽然之前在秀丽隐杆线虫中已经描述了许多游离重复片段，但这些都未显示能与正常同源染色体配对。假设秀丽隐杆线虫染色体中存在果蝇染色体中所描述类型的配对位点（I. 桑德勒，1956年；霍利，1980年），那么本文所描述的重复片段的减数分裂行为就可以得到理解。
