先天性无胸腺（裸）小鼠对孢子丝菌病的易感性。
Susceptibility of congenitally athymic (nude) mice to sporotrichosis.
作者信息
Dickerson C L, Taylor R L, Drutz D J
出版信息
Infect Immun. 1983 Apr;40(1):417-20. doi: 10.1128/iai.40.1.417-420.1983.
Abstract
Congenitally athymic (nu/nu) mice were found to be more susceptible to intravenous challenge with Sporothrix schenckii than their phenotypically normal (nu/+) littermates as measured by lethality and the number of viable yeast cells in the liver 7 days postinfection. Thymus reconstitution of nu/nu mice (nu/thy) conferred a significant degree of resistance to sporotrichosis. Immunization greatly enhanced the resistance of nu/thy and nu/+ mice, but unexpectedly increased the susceptibility of nu/nu mice. The susceptibility of nonimmunized nu/nu mice and the finding that thymus transplants augmented resistance to sporotrichosis suggest that T lymphocytes are critical to host defense.
摘要
通过观察致死率以及感染7天后肝脏中活酵母细胞数量发现，先天性无胸腺（nu/nu）小鼠比其表型正常（nu/+）的同窝小鼠更易受到申克孢子丝菌静脉攻击。对nu/nu小鼠进行胸腺重建（nu/thy）可使其对孢子丝菌病产生显著程度的抗性。免疫大大增强了nu/thy和nu/+小鼠的抗性，但出乎意料的是，却增加了nu/nu小鼠的易感性。未免疫的nu/nu小鼠的易感性以及胸腺移植增强对孢子丝菌病抗性这一发现表明，T淋巴细胞对宿主防御至关重要。
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