Velluti G, Capelli O, Lusuardi M, Braghiroli A, Pellegrino M, Milanti G, Benedetti L
Respiration. 1983;44(6):403-10. doi: 10.1159/000194577.
Bronchoalveolar lavage was performed on 12 healthy volunteers, comprising 6 smokers and 6 nonsmokers, of ages between 21 and 52 years. The aim was to define normal variability of certain biochemical, immunologic, enzymologic and ionic parameters. The smoking habit was observed to exert a significant influence on the recovery percentage of lavage effluents (with recovery less in smokers, 53 vs. 69%) and particularly on the concentration of immunoglobulins in the lavage liquids. In particular, the IgG increased by about 4 times in smokers (1.05 vs. 0.26 mg/100 ml) and the IgA by about 3 times (0.35 vs. 0.11 mg/100 ml). The other parameters studied (total proteins, albumins, IgM, alpha 1-AT, K, Ca and several enzyme activities) did not differ significantly from one group to the other. Rather than an alteration in the blood-alveolar barrier from smoking, these data suggest a real local overproduction of immunoglobulins of classes G and A induced by the smoking habit. Moreover, the relatively slight individual oscillation in the values of the parameters studied in the two groups supports the possibility of employing them for diagnostic purposes in bronchopneumopathies.
对12名年龄在21岁至52岁之间的健康志愿者进行了支气管肺泡灌洗，其中包括6名吸烟者和6名非吸烟者。目的是确定某些生化、免疫、酶学和离子参数的正常变异性。观察到吸烟习惯对灌洗流出物的回收率有显著影响（吸烟者回收率较低，分别为53%和69%），尤其对灌洗液体中免疫球蛋白的浓度有影响。具体而言，吸烟者的IgG增加了约4倍（1.05对0.26mg/100ml），IgA增加了约3倍（0.35对0.11mg/100ml）。所研究的其他参数（总蛋白、白蛋白、IgM、α1-抗胰蛋白酶、钾、钙和几种酶活性）在两组之间没有显著差异。这些数据表明，不是吸烟导致血-肺泡屏障改变，而是吸烟习惯真正导致了G类和A类免疫球蛋白的局部过度产生。此外，两组中所研究参数值相对较小的个体波动支持了将它们用于支气管肺炎诊断目的的可能性。
