肠道常驻菌群由宿主的遗传特征决定。对克罗恩病有何影响？

The resident faecal flora is determined by genetic characteristics of the host. Implications for Crohn's disease?

作者信息

Van de Merwe J P, Stegeman J H, Hazenberg M P

出版信息

Antonie Van Leeuwenhoek. 1983 Jun;49(2):119-24. doi: 10.1007/BF00393669.

Abstract

Recently, an "abnormal" faecal flora has been associated with Crohn's disease, a disease of unknown origin but with pertinent genetic predisposition. Therefore, it was investigated whether the faecal flora is under genetic influence in groups of monozygotic and dizygotic twins. Faecal floras of monozygotic twin siblings were found to be much more alike than those of dizygotic twin siblings. It is concluded that the resident faecal flora is under genetic influence and may be useful parameter to study possible genetic backgrounds of other diseases.

摘要

最近，一种“异常”的粪便菌群已与克罗恩病联系起来，这是一种病因不明但有相关遗传易感性的疾病。因此，研究了在同卵双胞胎和异卵双胞胎群体中，粪便菌群是否受遗传影响。结果发现，同卵双胞胎兄弟姐妹的粪便菌群比异卵双胞胎兄弟姐妹的更为相似。得出的结论是，常驻粪便菌群受遗传影响，可能是研究其他疾病潜在遗传背景的有用参数。