Lamers C B, Diemel C M, Jansen J B
Dig Dis Sci. 1984 Feb;29(2):102-8. doi: 10.1007/BF01317049.
Plasma pancreatic polypeptide (PP) responses to food, secretin (1 CU/kg, intravenous) and bombesin (60 pmol/kg/20 min intravenous) were compared in 14 normal subjects and in 17 patients with chronic pancreatitis and pancreatic insufficiency. Basal plasma PP concentrations were significantly higher in normal subjects than in patients with chronic pancreatitis, but there was considerable overlap between the groups. Ingestion of food induced significant increases in plasma PP both in normal subjects and in patients with chronic pancreatitis, whereas secretin and bombesin significantly increased plasma PP levels in normal subjects only. The PP responses to the three stimuli were significantly larger in normal subjects than in patients with chronic pancreatitis, but there was marked overlap. Calculation of the peak to basal plasma PP ratio did not result in better discrimination between the two groups. In normal subjects there were no significant correlations between the PP responses to the three stimuli, whereas in patients with chronic pancreatitis these responses were significantly correlated. Furthermore, in patients with chronic pancreatitis the PP responses to the various stimuli were significantly correlated with the basal plasma PP level.
在14名正常受试者以及17名患有慢性胰腺炎和胰腺功能不全的患者中，比较了血浆胰多肽（PP）对食物、促胰液素（1 CU/kg，静脉注射）和蛙皮素（60 pmol/kg/20分钟，静脉注射）的反应。正常受试者的基础血浆PP浓度显著高于慢性胰腺炎患者，但两组之间存在相当大的重叠。摄入食物可使正常受试者和慢性胰腺炎患者的血浆PP均显著升高，而促胰液素和蛙皮素仅使正常受试者的血浆PP水平显著升高。正常受试者对这三种刺激的PP反应显著大于慢性胰腺炎患者，但存在明显重叠。计算血浆PP峰值与基础值之比并不能更好地区分两组。在正常受试者中，对这三种刺激的PP反应之间无显著相关性，而在慢性胰腺炎患者中，这些反应显著相关。此外，在慢性胰腺炎患者中，对各种刺激的PP反应与基础血浆PP水平显著相关。
