Malhotra K M, Murthy R C, Srivastava R S, Chandra S V
J Appl Toxicol. 1984 Feb;4(1):22-5. doi: 10.1002/jat.2550040105.
Iron-deficient rats were co-exposed to manganese and lead to study lipid peroxide formation and contents of lead, manganese, copper, iron, zinc and calcium in the brain. Concurrent exposure to lead and manganese increased the lipid peroxidation potential of brain in iron-deficient rats. The concentration of lead, manganese and copper in the brain of iron-deficient rats increased to a greater magnitude after concurrent exposure to manganese and lead, compared with that observed after the exposure of either of the metals alone. Since copper is a potent inhibitor of transport ATPase in the brain, its significant increase, coupled with increased lipid peroxidation in the brain of iron-deficient rats, may be responsible for enhanced susceptibility of iron-deficient rats to the neurotoxic effects after the combined exposure to lead and manganese.
缺铁大鼠同时暴露于锰和铅环境中，以研究脂质过氧化物的形成以及大脑中铅、锰、铜、铁、锌和钙的含量。缺铁大鼠同时暴露于铅和锰会增加其大脑脂质过氧化的可能性。与单独暴露于其中任何一种金属后相比，缺铁大鼠在同时暴露于锰和铅后，大脑中铅、锰和铜的浓度升高幅度更大。由于铜是大脑中转运ATP酶的强效抑制剂，其显著增加，再加上缺铁大鼠大脑中脂质过氧化增加，可能是缺铁大鼠在同时暴露于铅和锰后对神经毒性作用易感性增强的原因。
