Bartrop R W, Luckhurst E, Lazarus L, Kiloh L G, Penny R
Lancet. 1977 Apr 16;1(8016):834-6. doi: 10.1016/s0140-6736(77)92780-5.
During 1975 twenty-six bereaved spouses took part in a detailed prospective investigation of the effects of severe stress on the immune system. T and B cell numbers and function, and hormone concentrations were studied approximately 2 weeks after bereavement and 6 weeks thereafter. The response to phytohaemagglutinin was significantly depressed in the bereaved group on the second occasion, as was the response to concanavalin A at 6 weeks. There was no difference in T and B cell numbers, protein concentrations, the presence of autoantibodies and delayed hypersensitivity, and in cortisol, prolactin, growth hormone, and thyroid hormone assays between the bereaved group and the controls. This is the first time severe psychological stress has been shown to produce a measurable abnormality in immune function which is not obviously caused by hormonal changes.
1975年期间，26位丧偶配偶参与了一项关于严重应激对免疫系统影响的详细前瞻性研究。在丧亲后约2周及之后6周，对T细胞和B细胞的数量与功能以及激素浓度进行了研究。在第二次检测时，丧亲组对植物血凝素的反应显著降低，6周时对刀豆球蛋白A的反应也是如此。丧亲组与对照组在T细胞和B细胞数量、蛋白质浓度、自身抗体的存在及迟发型超敏反应，以及皮质醇、催乳素、生长激素和甲状腺激素检测方面均无差异。这是首次表明严重心理应激会导致免疫功能出现可测量的异常，且这种异常并非明显由激素变化引起。
