小鼠α干扰素基因的染色体定位。
The chromosomal location of mouse interferon alpha genes.
作者信息
Lovett M, Cox D R, Yee D, Boll W, Weissmann C, Epstein C J, Epstein L B
出版信息
EMBO J. 1984 Jul;3(7):1643-6. doi: 10.1002/j.1460-2075.1984.tb02023.x.
Abstract
The chromosomal location of mouse leukocyte-interferon (IFN-alpha) genes was determined by Southern blot analysis of DNA from a panel of Chinese hamster x mouse somatic cell hybrids using a mouse IFN-alpha cDNA as a hybridization probe. All resolvable mouse genes are located on mouse chromosome 4. In addition, two common restriction site polymorphisms within these genes were identified in several mouse strains.
摘要
利用小鼠α干扰素（IFN-α）cDNA作为杂交探针，通过对一组中国仓鼠与小鼠体细胞杂种的DNA进行Southern印迹分析，确定了小鼠白细胞干扰素（IFN-α）基因的染色体定位。所有可分辨的小鼠基因都位于小鼠4号染色体上。此外，在几个小鼠品系中鉴定出了这些基因内的两个常见限制性酶切位点多态性。
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