Donnez J, Casanas-Roux F, Ferin J, Thomas K
Eur J Obstet Gynecol Reprod Biol. 1984 Jun;17(4):293-9. doi: 10.1016/0028-2243(84)90072-8.
Microbiopsies of 191 fimbriae were obtained from 146 patients undergoing laparotomy for acute salpingitis, or tubal surgery after salpingitis. The biopsies were classified in four groups according to the diagnosis at laparotomy: salpingitis, distal occlusion, peritubal adhesions or tuberculosis. The biopsies belonging to the group of distal occlusion were further classified in four sub-groups according to the extent of the lesions observed during the hysterosalpingography and laparoscopy. Since the crucial role of the ciliated epithelium in the ovum transport has been established, the percentage of ciliated cells and the epithelial height were determined in the groups and compared to those observed in fimbriae obtained from fertile women during an ovulatory cycle. Significant differences were noted in all groups when compared to fertile women. Acute salpingitis provoked a rapid and severe deciliation which recovered 3 months after triantibiotherapy. In the groups of distal occlusion, there was a significant correlation between the rate of deciliation and the extent of lesions. This suggests that deciliation of tubal epithelium is a sequela of salpingitis and that the extent of disease allows a prognosis of the percentage of ciliated cells.
从146例因急性输卵管炎接受剖腹手术或输卵管炎后接受输卵管手术的患者身上获取了191个输卵管伞端的组织活检样本。根据剖腹手术时的诊断，将活检样本分为四组：输卵管炎、远端阻塞、输卵管周围粘连或结核。属于远端阻塞组的活检样本根据子宫输卵管造影和腹腔镜检查中观察到的病变程度进一步分为四个亚组。由于已确定纤毛上皮在卵子运输中的关键作用，因此测定了各亚组中的纤毛细胞百分比和上皮高度，并与排卵周期中从有生育能力的女性身上获取的输卵管伞端样本进行比较。与有生育能力的女性相比，所有组均有显著差异。急性输卵管炎引发快速且严重的纤毛脱落，三联抗生素治疗3个月后纤毛恢复。在远端阻塞组中，纤毛脱落率与病变程度之间存在显著相关性。这表明输卵管上皮的纤毛脱落是输卵管炎的后遗症，并且疾病的程度可以对纤毛细胞百分比进行预后判断。
