Lenski R E
J Theor Biol. 1984 Jun 7;108(3):319-25. doi: 10.1016/s0022-5193(84)80035-1.
The assertion that the coevolution of bacteria and bacteriophage leads to an endless arms race between resistant bacterial mutants and corresponding host-range phage mutants is questioned. In general, structural constraints on the highly site-specific phage adsorption process appear more severe than physiological constraints on resource assimilation by bacteria. Several alternative hypotheses are presented that could account for the persistence of phage, despite this fundamental asymmetry in the coevolutionary potential of bacteria and phage.
细菌与噬菌体的共同进化会导致抗性细菌突变体与相应宿主范围噬菌体突变体之间无休止的军备竞赛这一观点受到质疑。一般来说，高度位点特异性的噬菌体吸附过程所受到的结构限制，似乎比细菌资源同化所受到的生理限制更为严格。尽管细菌和噬菌体在共同进化潜力上存在这种基本的不对称性，但仍提出了几种替代假说，来解释噬菌体为何能够持续存在。
