Wald N, Doll R, Copeland G
Br Med J (Clin Res Ed). 1981 Mar 7;282(6266):763-5. doi: 10.1136/bmj.282.6266.763.
The tar, nicotine, and carbon monoxide yields of cigarettes manufactured in the United Kingdom between 1934 and 1979 were studied. Over this period the average tar yield decreased by 49%, the nicotine yield by 31%, the carbon monoxide yield by 11%, all estimated on a sales-weighted basis. The average tar yield decreased progressively after the second world war, owing both to the introduction of filter cigarettes and to changes in the manufacture of plain cigarettes. The average nicotine yield increased initially, decreased by 43% from about 1950 to 1974, but increased again by 9% between 1974 and 1979. The average carbon monoxide yield started to decrease after about 1961; while it decreased substantially in plain cigarettes, the rapid increase in sales of filter cigarettes at this time, at the expense of plain cigarettes, largely offset the reduction in carbon monoxide yield that would otherwise have occurred. As with nicotine, carbon monoxide yield showed a small rise in later years (4% between 1976 and 1979). The trends in tar yield may well explain the reduction in lung cancer in the UK better than has been suspected hitherto. The trends in nicotine and carbon monoxide yields are probably not sufficiently different to distinguish which of them might be the more likely cause of cardiovascular disease.
对1934年至1979年间在英国制造的香烟的焦油、尼古丁和一氧化碳产量进行了研究。在此期间,按销售加权计算,平均焦油产量下降了49%,尼古丁产量下降了31%,一氧化碳产量下降了11%。第二次世界大战后,平均焦油产量逐渐下降,这既是由于过滤嘴香烟的引入,也是由于普通香烟制造工艺的变化。平均尼古丁产量最初有所增加,从1950年到1974年下降了43%,但在1974年至1979年间又增加了9%。平均一氧化碳产量在1961年左右开始下降;虽然普通香烟中的一氧化碳产量大幅下降,但此时过滤嘴香烟销量的迅速增加,以普通香烟为代价,在很大程度上抵消了一氧化碳产量本应出现的下降。与尼古丁一样,一氧化碳产量在后期也有小幅上升(1976年至1979年间上升了4%)。焦油产量的趋势很可能比迄今人们所怀疑的更能解释英国肺癌发病率的下降。尼古丁和一氧化碳产量的趋势可能没有足够的差异来区分它们中哪一个更可能是心血管疾病的病因。