异核体中鸡红细胞核的重新激活导致成年鸡珠蛋白基因的表达。
Reactivation of chicken erythrocyte nuclei in heterokaryons results in expression of adult chicken globin genes.
作者信息
Linder S, Zuckerman S H, Ringertz N R
出版信息
Proc Natl Acad Sci U S A. 1981 Oct;78(10):6286-9. doi: 10.1073/pnas.78.10.6286.
Abstract
Activation of chicken globin gene transcription has been demonstrated in chicken erythrocyte--rat L6 myoblast heterokaryons. The globin mRNA is polyadenylylated and is translated into adult chicken alpha A-, alpha D-, and beta-globin polypeptides. No fetal globin mRNA or globin polypeptides were detected. Heterokaryons between chicken erythrocytes and mouse neuroblastoma cells or hamster BHK cells also synthesized adult chicken globins.
摘要
在鸡红细胞与大鼠L6成肌细胞的异核体中已证实鸡珠蛋白基因转录被激活。珠蛋白mRNA进行了多聚腺苷酸化，并被翻译成成年鸡的αA-、αD-和β珠蛋白多肽。未检测到胎儿珠蛋白mRNA或珠蛋白多肽。鸡红细胞与小鼠神经母细胞瘤细胞或仓鼠BHK细胞之间的异核体也合成成年鸡珠蛋白。
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