钠钾协同转运活性作为原发性高血压的遗传标志物。
Sodium-potassium cotransport activity as genetic marker in essential hypertension.
作者信息
Davidson J S, Opie L H, Keding B
出版信息
Br Med J (Clin Res Ed). 1982 Feb 20;284(6315):539-41. doi: 10.1136/bmj.284.6315.539.
Abstract
Sodium-potassium cotransport activity is thought to be defective in essential hypertension and could be a useful genetic marker for susceptibility to essential hypertension. In this study cotransport activity in subjects with hypertension was compared with that in normotensive controls. The effects of ethnic differences, environment, and antihypertensive drugs were also studied. Mean cotransport activity was lower in hypertensive subjects than in controls of the same ethnic groups. There was, however, a large overlap between controls and hypertensive subjects. No ethnic or environmental influences were found. The large overlap found suggests that sodium-potassium cotransport activity is not a useful genetic marker in essential hypertension.
摘要
钠钾协同转运活性被认为在原发性高血压中存在缺陷，并且可能是原发性高血压易感性的一个有用的遗传标志物。在本研究中，将高血压患者的协同转运活性与血压正常的对照组进行了比较。还研究了种族差异、环境和抗高血压药物的影响。高血压患者的平均协同转运活性低于同种族的对照组。然而，对照组和高血压患者之间存在很大的重叠。未发现种族或环境影响。所发现的巨大重叠表明钠钾协同转运活性在原发性高血压中不是一个有用的遗传标志物。
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