氨基糖苷类药物在大鼠肾实质中的蓄积动力学。
Aminoglycoside accumulation kinetics in rat renal parenchyma.
作者信息
Aronoff G R, Pottratz S T, Brier M E, Walker N E, Fineberg N S, Glant M D, Luft F C
出版信息
Antimicrob Agents Chemother. 1983 Jan;23(1):74-8. doi: 10.1128/AAC.23.1.74.
Abstract
To test the hypotheses that the renal parenchymal accumulation kinetics of aminoglycosides can predict nephrotoxicity, we measured renal parenchymal concentrations in rats receiving gentamicin and tobramycin. In addition to comparing the drugs as single daily injections, we also examined the effect of multiple doses versus a single daily dose. Gentamicin accumulated to much greater concentrations in the kidney than did tobramycin. Gentamicin given twice daily accumulated more rapidly and to greater concentrations than did the same total dose given once daily. We conclude that aminoglycoside accumulation in the kidney depends on the drug and dose regimen. These differences may explain relative nephrotoxicities.
摘要
为了验证氨基糖苷类药物在肾实质中的蓄积动力学能否预测肾毒性这一假说，我们测定了接受庆大霉素和妥布霉素的大鼠肾实质浓度。除了比较单次每日注射给药的药物外，我们还研究了多次给药与单次每日给药的效果。庆大霉素在肾脏中的蓄积浓度远高于妥布霉素。每日两次给药的庆大霉素比每日一次给予相同总剂量的庆大霉素蓄积更快且浓度更高。我们得出结论，氨基糖苷类药物在肾脏中的蓄积取决于药物和给药方案。这些差异可能解释了相对肾毒性。
相似文献
1
Aminoglycoside accumulation kinetics in rat renal parenchyma.氨基糖苷类药物在大鼠肾实质中的蓄积动力学。
Antimicrob Agents Chemother. 1983 Jan;23(1):74-8. doi: 10.1128/AAC.23.1.74.
2
Choice of drug and dosage regimen. Two important risk factors for aminoglycoside nephrotoxicity.药物及给药方案的选择。氨基糖苷类药物肾毒性的两个重要风险因素。
Am J Med. 1986 Jun 30;80(6B):115-8. doi: 10.1016/0002-9343(86)90488-2.
3
Relationship between rat renal accumulation of gentamicin, tobramycin, and netilmicin and their nephrotoxicities.庆大霉素、妥布霉素和奈替米星在大鼠肾脏中的蓄积与其肾毒性之间的关系。
Antimicrob Agents Chemother. 1985 May;27(5):812-6. doi: 10.1128/AAC.27.5.812.
4
Aminoglycoside accumulation in the second compartment of kidney cell.氨基糖苷类药物在肾细胞第二部分中的蓄积。
Dev Toxicol Environ Sci. 1986;14:101-4.
5
Correlation between renal membrane binding and nephrotoxicity of aminoglycosides.氨基糖苷类药物的肾膜结合与肾毒性之间的相关性。
Antimicrob Agents Chemother. 1987 Apr;31(4):570-4. doi: 10.1128/AAC.31.4.570.
6
Comparative study on renal accumulation of aminoglycoside antibiotics.氨基糖苷类抗生素肾脏蓄积的比较研究。
Int J Clin Pharmacol Ther Toxicol. 1985 Jan;23(1):47-51.
7
Molecular aspects of renal handling of aminoglycosides and strategies for preventing the nephrotoxicity.氨基糖苷类药物肾脏处理的分子机制及预防肾毒性的策略
Drug Metab Pharmacokinet. 2004 Jun;19(3):159-70. doi: 10.2133/dmpk.19.159.
8
Renal ultrastructural and biochemical injuries induced by aminoglycosides.氨基糖苷类药物引起的肾脏超微结构和生化损伤。
Environ Health Perspect. 1984 Aug;57:293-9. doi: 10.1289/ehp.8457293.
9
The effect of dosing strategy on kidney cortical accumulation of aminoglycosides in rats.给药策略对大鼠肾皮质中氨基糖苷类药物蓄积的影响。
Am J Kidney Dis. 1986 Nov;8(5):297-303. doi: 10.1016/s0272-6386(86)80101-9.
10
Comparative nephrotoxicity of four aminoglycosides: biochemical and ultrastructural modifications of lysosomes.四种氨基糖苷类药物的比较肾毒性：溶酶体的生化及超微结构改变
Adv Nephrol Necker Hosp. 1983;12:253-75.
引用本文的文献
1
The Essential Oils Inhibited Inflammation and Apoptosis through p38/JNK MAPK Signaling Pathway and Alleviated Gentamicin-Induced Acute Kidney Injury.这些精油通过 p38/JNK MAPK 信号通路抑制炎症和细胞凋亡，并缓解庆大霉素诱导的急性肾损伤。
Molecules. 2022 Oct 21;27(20):7121. doi: 10.3390/molecules27207121.
2
The minor gentamicin complex component, X2, is a potent premature stop codon readthrough molecule with therapeutic potential.小分子庆大霉素复合物成分 X2 是一种有效的提前终止密码子通读分子，具有治疗潜力。
PLoS One. 2018 Oct 25;13(10):e0206158. doi: 10.1371/journal.pone.0206158. eCollection 2018.
3
Pharmacokinetic profile that reduces nephrotoxicity of gentamicin in a perfused kidney-on-a-chip.在芯片上构建的灌流肾模型中降低庆大霉素肾毒性的药代动力学特征。
Biofabrication. 2016 Mar 24;8(1):015021. doi: 10.1088/1758-5090/8/1/015021.
4
Use of aminoglycosides in elderly patients. Pharmacokinetic and clinical considerations.老年患者中氨基糖苷类药物的使用。药代动力学及临床考量。
Drugs Aging. 1997 Apr;10(4):259-77. doi: 10.2165/00002512-199710040-00003.
5
Single or multiple daily doses of aminoglycosides: a meta-analysis.氨基糖苷类药物每日单次或多次给药：一项荟萃分析。
BMJ. 1996 Feb 10;312(7027):338-45. doi: 10.1136/bmj.312.7027.338.
6
Gentamicin, netilmicin, dibekacin, and amikacin nephrotoxicity and its relationship to tubular reabsorption in rabbits.庆大霉素、奈替米星、地贝卡星和阿米卡星对家兔的肾毒性及其与肾小管重吸收的关系。
Antimicrob Agents Chemother. 1984 Feb;25(2):168-72. doi: 10.1128/AAC.25.2.168.
7
Induction and inhibition of pinocytosis by aminoglycoside antibiotics.氨基糖苷类抗生素对胞饮作用的诱导与抑制
Br J Pharmacol. 1984 Nov;83(3):615-23. doi: 10.1111/j.1476-5381.1984.tb16215.x.
8
Relationship between rat renal accumulation of gentamicin, tobramycin, and netilmicin and their nephrotoxicities.庆大霉素、妥布霉素和奈替米星在大鼠肾脏中的蓄积与其肾毒性之间的关系。
Antimicrob Agents Chemother. 1985 May;27(5):812-6. doi: 10.1128/AAC.27.5.812.
9
Renal cortical kinetics of gentamicin after implantation of gentamicin-polymethylmethacrylate beads in rats.庆大霉素-聚甲基丙烯酸甲酯珠植入大鼠后庆大霉素的肾皮质动力学
Antimicrob Agents Chemother. 1986 Sep;30(3):385-9. doi: 10.1128/AAC.30.3.385.
10
Improved sodium hydroxide digestion method without homogenization for extraction of gentamicin from renal tissue.改良的无需匀浆的氢氧化钠消化法用于从肾组织中提取庆大霉素。
Antimicrob Agents Chemother. 1988 Apr;32(4):595-7. doi: 10.1128/AAC.32.4.595.
本文引用的文献
1
Comparative nephrotoxicity of gentamicin and tobramycin: pharmacokinetic and clinical studies in 201 patients.庆大霉素与妥布霉素的肾毒性比较：201例患者的药代动力学及临床研究
Antimicrob Agents Chemother. 1981 May;19(5):859-66. doi: 10.1128/AAC.19.5.859.
2
Renal parenchymal accumulation of aminoglycoside antibiotics in rats.大鼠肾实质中氨基糖苷类抗生素的蓄积
J Infect Dis. 1974 Dec;130(6):656-9. doi: 10.1093/infdis/130.6.656.
3
Pharmacologic factors associated with gentamicin nephrotoxicity in rabbits.与家兔庆大霉素肾毒性相关的药理学因素。
J Infect Dis. 1977 Jun;135(6):952-6. doi: 10.1093/infdis/135.6.952.
4
Comparative nephrotoxicity of aminoglycoside antibiotics in rats.氨基糖苷类抗生素对大鼠的比较肾毒性
J Infect Dis. 1978 Oct;138(4):541-5. doi: 10.1093/infdis/138.4.541.
5
Nephrotoxicity of gentamicin and tobramycin given once daily or continuously in dogs.庆大霉素和妥布霉素每日一次或持续给药对犬的肾毒性
J Antimicrob Chemother. 1978 May;4 Suppl A:85-101. doi: 10.1093/jac/4.suppl_a.85.
6
Comparative nephrotoxicity of gentamicin and tobramycin in rats.庆大霉素和妥布霉素对大鼠的肾毒性比较
Antimicrob Agents Chemother. 1978 Jan;13(1):34-40. doi: 10.1128/AAC.13.1.34.
7
Mlab--a mathematical modeling tool.Mlab——一种数学建模工具。
Comput Programs Biomed. 1979 Dec;10(3):271-80. doi: 10.1016/0010-468x(79)90075-8.
8
The influence of dosage regimen on experimental gentamicin nephrotoxicity: dissociation of peak serum levels from renal failure.给药方案对实验性庆大霉素肾毒性的影响：血清峰值水平与肾衰竭的分离
J Infect Dis. 1979 Oct;140(4):576-80. doi: 10.1093/infdis/140.4.576.
Zotero 插件