Müller G, Bruns M, Martínez Peralta L, Lehmann-Grube F
Arch Virol. 1983;75(4):229-42. doi: 10.1007/BF01314889.
The structure of lymphocytic choriomeningitis virus (LCM virus) was investigated by a variety of conventional as well as novel electron microscopic procedures. Thin sections of infected cells revealed the characteristic arenavirus entities whose interiors contain ribosome-like granules but look otherwise empty. In contrast, most thin-sectioned virus particles from infectious cell culture fluid, both untreated and highly purified with little loss of initial infectivity, appeared to be filled with rather homogeneous cores. Cores rather than granules were also found in positively contrasted whole and thin-sectioned virus particles. We favor the explanation that the sandy grains, which have given this group of viruses its name, are altered cores that happen to look like ribosomes. However, the alternative cannot yet be excluded, namely, that LCM virus-infected cells produce two types of particles, of which only the core-containing ones represent virions.
通过多种传统及新颖的电子显微镜方法对淋巴细胞性脉络丛脑膜炎病毒（LCM病毒）的结构进行了研究。感染细胞的超薄切片显示出特征性的沙粒样病毒粒子，其内部含有核糖体样颗粒，但其他部分看似为空。相比之下，来自感染性细胞培养液的大多数超薄切片病毒粒子，无论是未经处理的还是经过高度纯化且初始感染力损失很小的，似乎都充满了相当均匀的核心。在正染色的完整和超薄切片病毒粒子中也发现了核心而非颗粒。我们倾向于这样一种解释，即赋予这组病毒名称的沙粒样颗粒是发生改变的核心，碰巧看起来像核糖体。然而，另一种可能性也尚未排除，即LCM病毒感染的细胞产生两种类型的粒子，其中只有含核心的粒子代表病毒体。
