Porter G A
Ann Intern Med. 1983 May;98(5 Pt 2):720-3. doi: 10.7326/0003-4819-98-5-720.
The observations that have provided the foundation of the sodium hypothesis of human hypertension are reviewed. Clinical observations made over 125 years ago initiated an investigative effort that has encompassed epidemiologic data, development of salt-related experimental models, and elucidation of theoretical mechanisms that interface Na+ balance with abnormal regulation of peripheral vascular resistance. In spite of the data available, a consensus is lacking on the relevance of applying the link between sodium intake and increased blood pressure in certain hypertensive patients to all persons.
回顾了为人类高血压钠假说奠定基础的观察结果。125多年前的临床观察开启了一项研究工作，该工作涵盖了流行病学数据、盐相关实验模型的开发以及阐明将钠平衡与外周血管阻力异常调节相联系的理论机制。尽管有现有数据，但对于将某些高血压患者钠摄入量与血压升高之间的联系应用于所有人的相关性，仍缺乏共识。
