Stibler H, Allgulander C, Borg S, Kjellin K G
Acta Med Scand. 1978;204(1-2):49-56. doi: 10.1111/j.0954-6820.1978.tb08397.x.
The serum and CSF proteins were analyzed by isoelectric focusing in 16 male alcoholics after alcohol intoxication and after 10--14 days of alcohol abstinence. An abnormally marked protein band with pI 5.7 was found in serum in 15 patients and in CSF in 12 at the first examination. On crossed immunoelectrofocusing it appeared as an increased, cathodal, microheterogeneous molecular form of transferrin. The abnormality was reversible and decreased or normalized in serum in all cases after abstinence. In 6 patients with clinical signs of cerebellar degeneration, an abnormal microheterogeneous pattern of CSF transferrin of partly different appearance to that in serum remained after abstinence. Disturbed liver synthesis of transferrin is a probable origin of the serum finding, which may be specifically related to alcohol abuse. Substitution or loss of acidic amino acids and/or decreased iron binding ability are possible structural explanations.
对16名男性酗酒者在酒精中毒后及戒酒10 - 14天后的血清和脑脊液蛋白质进行等电聚焦分析。首次检查时，15例患者血清中及12例患者脑脊液中发现一条异常明显的等电点为5.7的蛋白带。在交叉免疫电聚焦中，它表现为转铁蛋白增加的、向阴极移动的、微不均一的分子形式。这种异常是可逆的，戒酒之后所有病例血清中的该异常均降低或恢复正常。6例有小脑变性临床体征的患者，戒酒之后脑脊液中转铁蛋白仍呈现异常的微不均一模式，其外观与血清中的部分不同。转铁蛋白肝脏合成紊乱可能是血清中这一发现的根源，这可能与酒精滥用有特定关系。酸性氨基酸的取代或缺失和/或铁结合能力降低是可能的结构解释。
