接受脑肿瘤治疗的儿童生长发育受损。
Growth impairment in children treated for brain tumours.
作者信息
Shalet S M, Beardwell C G, Aarons B M, Pearson D, Jones P H
出版信息
Arch Dis Child. 1978 Jun;53(6):491-4. doi: 10.1136/adc.53.6.491.
Abstract
Growth and growth hormone (GH) secretion were studied in 14 children with brain tumours before radiation and chemotherapy and at various time intervals afterwards. The peak GH response to hypoglycaemia was normal in all patients before radiation. In 6 patients the peak GH response was impaired 1 year after radiation, and in a seventh it was normal at 1 year but impaired 2 years after radiation. In 12 of 13 patients the growth velocity during the first year of chemotherapy was below the 3rd centile, although none of these had an initial standing height below the 3rd centile. Thus it appears that poor growth in such children occurs irrespective of whether radiation-induced GH deficiency develops. The cause of this impaired growth is unknown.
摘要
对14例脑肿瘤患儿在放疗和化疗前以及之后的不同时间间隔进行了生长和生长激素（GH）分泌的研究。所有患者放疗前对低血糖的GH峰值反应均正常。6例患者放疗后1年GH峰值反应受损，第7例患者放疗后1年反应正常，但2年后受损。13例患者中有12例在化疗的第一年生长速度低于第3百分位，尽管这些患者最初的身高均未低于第3百分位。因此，似乎这些儿童生长不良的发生与放疗引起的GH缺乏是否发展无关。这种生长受损的原因尚不清楚。
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