Cunha G R, Sekkingstad M, Meloy B A
Differentiation. 1983;24(2):174-80. doi: 10.1111/j.1432-0436.1983.tb01317.x.
Epithelia of embryonic urogenital sinuses (UGE) or embryonic or adult urinary bladders (BLE) were associated heterospecifically with mesenchyme of the embryonic urogenital sinus (UGM). The resultant chimeric tissue recombinants prepared with mouse, rat, rabbit, and human tissues were grown for 2 to 14 weeks in male athymic nude mice. For almost all categories of permissive (UGM + UGE) or instructive (UGM + BLE) inductions, prostatic epithelial development occurred. In recombinations of mouse UGM and human fetal BLE, the bladder epithelium was induced to form glandular structures. The morphogenetic process observed was similar to that normally expressed during human prostatic development. We conclude that the mechanism of prostatic development is similar in these mammalian species.
胚胎泌尿生殖窦（UGE）或胚胎及成年膀胱（BLE）的上皮与胚胎泌尿生殖窦间充质（UGM）进行异种特异性结合。用小鼠、大鼠、兔和人类组织制备的嵌合组织重组体在雄性无胸腺裸鼠体内生长2至14周。对于几乎所有类型的允许性（UGM + UGE）或诱导性（UGM + BLE）诱导，都发生了前列腺上皮发育。在小鼠UGM与人类胎儿BLE的重组中，膀胱上皮被诱导形成腺性结构。观察到的形态发生过程与人类前列腺发育过程中正常表达的过程相似。我们得出结论，这些哺乳动物物种中前列腺发育的机制是相似的。
