Simberkoff M S, Schiffman G, Katz L A, Spicehandler J R, Moldover N H, Rahal J J
J Lab Clin Med. 1980 Aug;96(2):363-70.
PCP vaccine was administered to 21 adult hemodialysis patients and 25 control patients with no renal nor hepatic dysfunction. Antibody concentrations measured by the RIA technique were lower in the hemodialysis than in the control patients in both prevaccination sera and specimens obtained 3 to 4 weeks following vaccination. However, 6 months after vaccination, RIA GMACs in hemodialysis and control subjects were more nearly alike. OTs against Streptococcus pneumoniae, types 1 and 3, were measured in paired sera from vaccine recipients. Opsonic activity against S. pneumoniae, type I, was detected as frequently in the 3 to 4 week postvaccine sera of the dialysis as in those of control patients. However, there was a poor correlation between OTs and RIA-ACs against this organism. There was good correlation between OT and RIA-AC against type 3 pneumococci in 3 to 4 week postvaccine sera, and significantly more control patients had opsonic activity detectable in these specimens. No clinical S. pneumoniae infections have been observed in vaccine recipients. However, continued follow-up will be necessary to document the degree to which hemodialysis patients are protected by pneumococcal vaccines and the relationship between protection and antibody concentration or OTs.
对21例成年血液透析患者和25例无肾、肝功能障碍的对照患者接种了肺炎球菌多糖（PCP）疫苗。通过放射免疫分析（RIA）技术测定的抗体浓度显示，在接种疫苗前的血清以及接种后3至4周采集的样本中，血液透析患者的抗体浓度均低于对照患者。然而，接种疫苗6个月后，血液透析患者和对照受试者的RIA几何平均抗体浓度（GMACs）更为接近。在疫苗接种者的配对血清中检测了针对1型和3型肺炎链球菌的调理吞噬作用（OTs）。在透析患者接种疫苗后3至4周的血清中，检测到针对1型肺炎链球菌的调理活性的频率与对照患者相同。然而，针对该病原体的OTs与RIA抗体浓度（ACs）之间的相关性较差。在接种疫苗后3至4周的血清中，针对3型肺炎球菌的OTs与RIA-AC之间存在良好的相关性，并且在这些样本中，可检测到调理活性的对照患者明显更多。在疫苗接种者中未观察到临床肺炎链球菌感染。然而，有必要持续随访，以记录血液透析患者受肺炎球菌疫苗保护的程度以及保护作用与抗体浓度或OTs之间的关系。
