Barrell B G, Anderson S, Bankier A T, de Bruijn M H, Chen E, Coulson A R, Drouin J, Eperon I C, Nierlich D P, Roe B A, Sanger F, Schreier P H, Smith A J, Staden R, Young I G
Proc Natl Acad Sci U S A. 1980 Jun;77(6):3164-6. doi: 10.1073/pnas.77.6.3164.
Analysis of an almost complete mammalian mitochondrial DNA sequence has identified 23 possible tRNA genes and we speculate here that these are sufficient to translate all the codons of the mitochondrial genetic code. This number is much smaller than the minimum of 31 required by the wobble hypothesis. For each of the eight genetic code boxes with four codons for one amino acid we find a single specific tRNA gene with T in the first (wobble) position of the anticodon. We suggest that these tRNAs with U in the wobble position can recognize all four codons in these genetic code boxes either by a "two out of three" base interaction or by U.N wobble.
对几乎完整的哺乳动物线粒体DNA序列进行分析后，已鉴定出23个可能的tRNA基因，我们在此推测这些基因足以翻译线粒体遗传密码的所有密码子。这个数字远小于摆动假说所需的至少31个。对于八个遗传密码框中每个密码框有四个密码子对应一种氨基酸的情况，我们发现一个单一的特定tRNA基因，其反密码子的第一位（摆动位）为T。我们认为这些摆动位为U的tRNA可以通过“三分之二”碱基相互作用或U·N摆动识别这些遗传密码框中的所有四个密码子。
