哺乳动物线粒体tRNA对密码子的识别模式不同。
Different pattern of codon recognition by mammalian mitochondrial tRNAs.
作者信息
Barrell B G, Anderson S, Bankier A T, de Bruijn M H, Chen E, Coulson A R, Drouin J, Eperon I C, Nierlich D P, Roe B A, Sanger F, Schreier P H, Smith A J, Staden R, Young I G
出版信息
Proc Natl Acad Sci U S A. 1980 Jun;77(6):3164-6. doi: 10.1073/pnas.77.6.3164.
Abstract
Analysis of an almost complete mammalian mitochondrial DNA sequence has identified 23 possible tRNA genes and we speculate here that these are sufficient to translate all the codons of the mitochondrial genetic code. This number is much smaller than the minimum of 31 required by the wobble hypothesis. For each of the eight genetic code boxes with four codons for one amino acid we find a single specific tRNA gene with T in the first (wobble) position of the anticodon. We suggest that these tRNAs with U in the wobble position can recognize all four codons in these genetic code boxes either by a "two out of three" base interaction or by U.N wobble.
摘要
对几乎完整的哺乳动物线粒体DNA序列进行分析后，已鉴定出23个可能的tRNA基因，我们在此推测这些基因足以翻译线粒体遗传密码的所有密码子。这个数字远小于摆动假说所需的至少31个。对于八个遗传密码框中每个密码框有四个密码子对应一种氨基酸的情况，我们发现一个单一的特定tRNA基因，其反密码子的第一位（摆动位）为T。我们认为这些摆动位为U的tRNA可以通过“三分之二”碱基相互作用或U·N摆动识别这些遗传密码框中的所有四个密码子。
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本文引用的文献
1
A computer program to search for tRNA genes.一个用于搜索转运RNA基因的计算机程序。
Nucleic Acids Res. 1980 Feb 25;8(4):817-25.
2
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Proc Natl Acad Sci U S A. 1980 Jun;77(6):3167-70. doi: 10.1073/pnas.77.6.3167.
3
Novel features in the genetic code and codon reading patterns in Neurospora crassa mitochondria based on sequences of six mitochondrial tRNAs.基于六种线粒体tRNA序列的粗糙脉孢菌线粒体遗传密码和密码子阅读模式的新特征
Proc Natl Acad Sci U S A. 1980 Jun;77(6):3159-63. doi: 10.1073/pnas.77.6.3159.
4
Codon--anticodon pairing: the wobble hypothesis.密码子-反密码子配对：摆动假说
J Mol Biol. 1966 Aug;19(2):548-55. doi: 10.1016/s0022-2836(66)80022-0.
5
An electron microscope study of the relative positions of the 4S and ribosomal RNA genes in HeLa cells mitochondrial DNA.对海拉细胞线粒体DNA中4S和核糖体RNA基因相对位置的电子显微镜研究。
Cell. 1976 Sep;9(1):81-90. doi: 10.1016/0092-8674(76)90054-4.
6
Amino acid specificity of the transfer RNA species coded for by HeLa cell mitochondrial DNA.由海拉细胞线粒体DNA编码的转运RNA种类的氨基酸特异性。
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7
A strategy of DNA sequencing employing computer programs.一种采用计算机程序的DNA测序策略。
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8
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9
The use of exonuclease III for preparing single stranded DNA for use as a template in the chain terminator sequencing method.
Nucleic Acids Res. 1979 Mar;6(3):831-48. doi: 10.1093/nar/6.3.831.
10
Mammalian mitochondrial transfer RNAs: chromatographic properties, size and origin.哺乳动物线粒体转运核糖核酸：色谱特性、大小及起源
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