Sjögren B
Scand J Work Environ Health. 1980 Sep;6(3):197-200. doi: 10.5271/sjweh.2616.
Hexavalent chromium particles are generated in the welding of stainless steel. These particles have manifested a mutagenic action in bacterial test systems and produced chromosome aberrations in cultured Chinese hamster cells. Welders who had welded stainless steel for more than 5 a during 1950--1965 were selected for this study. According to an earlier survey the hexavalent chromium exposure of such welders was often about 50 microgram/m3 (calculated as CrO3). The cohort was followed until December 1977. The expected number of deaths was calculated from cause-, gender-, age-, and year-specific death rates of the general population in Sweden. In the cohort, consisting of 234 welders, the observed numbers of total deaths and deaths caused by tumors were the same as the expected numbers. However, three welders had died of pulmonary tumors in comparison to the expected number of 0.68 (p = 0.03).
六价铬颗粒在不锈钢焊接过程中产生。这些颗粒在细菌测试系统中已表现出诱变作用，并在培养的中国仓鼠细胞中产生染色体畸变。本研究选取了在1950年至1965年期间焊接不锈钢超过5年的焊工。根据早期调查，这类焊工的六价铬暴露量通常约为50微克/立方米（以CrO3计算）。该队列随访至1977年12月。预期死亡人数根据瑞典普通人群的死因、性别、年龄和年份特异性死亡率计算得出。在由234名焊工组成的队列中，总死亡人数和肿瘤所致死亡人数的观察值与预期值相同。然而，有3名焊工死于肺部肿瘤，而预期人数为0.68（p = 0.03）。
