Bauer R, Schultz-Ehrenburg U, Orfanos C E
Hautarzt. 1981 Jan;32(1):23-7.
A patient with discoid lupus erythematosus is reported which turned into a mixed connective tissue disease (MCTD) within five months. THe patient developed a severe polysymptomatic clinical picture with frailty, myositis, generalized erythema and livedo racemosa features, but without renal involvement. Combined therapy with prednisolone and azathioprine led to rapid regression of all symptoms. After releasing from the hospital a mitigated relapse could be controlled by increasing the dose of cortico-steroids. No other relapse occurred during the following year. Since the onset of disease the indirect immunofluorescence showed antinuclear antibodies of the speckled pattern. Also we could mark antibodies against ENA. We regard this finding as an indication, that in patients with discoid lupus erythematosus and antinuclear antibodies of the speckled pattern the risk of progressing into MCTD had to be considered. Repeated controls for symptoms of other collagenoses, therefore, should follow for a period of two years.
报告了一名盘状红斑狼疮患者，该患者在五个月内转变为混合性结缔组织病（MCTD）。患者出现了严重的多症状临床表现，包括身体虚弱、肌炎、全身性红斑和网状青斑特征，但无肾脏受累。泼尼松龙和硫唑嘌呤联合治疗导致所有症状迅速消退。出院后，通过增加皮质类固醇剂量可控制轻度复发。在接下来的一年中未发生其他复发。自疾病发作以来，间接免疫荧光显示斑点型抗核抗体。我们还可以标记抗ENA抗体。我们认为这一发现表明，对于患有盘状红斑狼疮且有斑点型抗核抗体的患者，必须考虑进展为MCTD的风险。因此，应在两年内对其他胶原病症状进行反复检查。
