Briggs L P, Clarke R S, Dundee J W, Moore J, Bahar M, Wright P J
Br J Anaesth. 1981 Nov;53(11):1197-202. doi: 10.1093/bja/53.11.1197.
The use of di-isopropyl phenol (Diprivan) for induction of anaesthesia was assessed in doses ranging from 1 to 3 mg kg-1. With less than 1.75mg kg-1 not all patients were anaesthetized; 2.0 mg kg-1 appeared to be a satisfactory induction dose. Involuntary muscle movement, cough and hiccup at induction were rare with any dose studied. However, the frequency of hypotension and respiratory depression were related to the dose given. Pain on injection was uncommon when the drug was given into an antecubital vein, but occurred in 39% of patients when injected to the back of the hand or wrist. Recovery was rapid, and characterized by lack of emetic sequelae. Di-isopropyl phenol 1.5 - 2.0 mg kg-1 given rapidly during reactive hyperaemia can produce anaesthesia in one arm-brain circulation time. A reaction involving flush, hypotension, cough, laryngospasm and bronchospasm occurred in one patient receiving 2.5 mg kg-1 given over 20 s.
对异丙酚（得普利麻）用于诱导麻醉进行了评估，剂量范围为1至3毫克/千克。剂量低于1.75毫克/千克时，并非所有患者都能被麻醉；2.0毫克/千克似乎是一个令人满意的诱导剂量。在所研究的任何剂量下，诱导时的不自主肌肉运动、咳嗽和打嗝都很少见。然而，低血压和呼吸抑制的发生率与给药剂量有关。将药物注入肘前静脉时注射疼痛不常见，但注入手背或手腕时，39%的患者会出现疼痛。恢复迅速，且无呕吐后遗症。在反应性充血期间快速给予1.5 - 2.0毫克/千克的异丙酚，可在一个臂-脑循环时间内产生麻醉效果。一名患者在20秒内接受2.5毫克/千克的剂量时，出现了包括脸红、低血压、咳嗽、喉痉挛和支气管痉挛在内的反应。
