氨甲环酸治疗溃疡性结肠炎
Tranexamic acid therapy in ulcerative colitis.
作者信息
Hollanders D, Thomson J M, Schofield P F
出版信息
Postgrad Med J. 1982 Feb;58(676):87-91. doi: 10.1136/pgmj.58.676.87.
Abstract
The antifibrinolytic drug tranexamic acid was assessed in controlling bleeding in 12 patients with left-sided proctocolitis. The study was designed as a double-blind cross-over trial employing a dose of 4·5 g of tranexamic acid/day together with identical placebo. A statistically significant reduction in rectal bleeding was achieved in 50% of cases with a minimum of side effects. Sigmoidoscopic grading of rectal mucosal appearances was improved. Frequency of diarrhoea and stool consistency were not altered. Tranexamic acid may have a part to play in the management of selected patients with ulcerative colitis in whom bleeding is difficult to control with orthodox treatment.
摘要
对12例左侧直肠结肠炎患者使用抗纤维蛋白溶解药物氨甲环酸控制出血情况进行了评估。该研究设计为双盲交叉试验，采用每日4.5克氨甲环酸加相同安慰剂的剂量。50%的病例直肠出血有统计学意义的显著减少，且副作用最小。直肠黏膜外观的乙状结肠镜分级得到改善。腹泻频率和大便稠度未改变。对于部分溃疡性结肠炎患者，若采用传统治疗难以控制出血，氨甲环酸可能会发挥作用。
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