Cook R R, Bodner K M, Kolesar R C, Uhlmann C S, VanPeenen P F, Dickson G S, Flanagan K
Arch Environ Health. 1982 Nov-Dec;37(6):346-51. doi: 10.1080/00039896.1982.10667589.
Human exposures to ethylene glycol monomethyl ether have been associated with hematological and neurological abnormalities. Recent animal toxicology studies have also reported testicular atrophy. To determine whether employees potentially exposed to ethylene glycol monomethyl ether during manufacturing and packaging had a higher prevalence of anemia, leukopenia, or sterility than an in-plant comparison group, a cross-sectional study was conducted at the Michigan Division of Dow Chemical U.S.A. Blood samples on 65 of 97 potentially exposed and control white males, and semen samples from a subset of 15 were analyzed. With the possible exception of smaller testicular size, no gross abnormalities or clinically meaningful differences in hematological or fertility indices were noted. Results of regression modeling suggested that white blood cells and hemoglobin might be decreased at higher exposure levels.
人类接触乙二醇单甲醚与血液学和神经学异常有关。近期的动物毒理学研究也报告了睾丸萎缩。为了确定在制造和包装过程中可能接触乙二醇单甲醚的员工是否比厂内对照组有更高的贫血、白细胞减少或不育患病率，在美国陶氏化学公司密歇根分部进行了一项横断面研究。对97名可能接触乙二醇单甲醚的白人男性和对照组中的65人采集了血样，并对其中15人的精液样本进行了分析。除了睾丸可能较小外，未发现明显异常，血液学指标或生育指标也无具有临床意义的差异。回归模型结果表明，在接触水平较高时白细胞和血红蛋白可能会减少。
