甲基-α-麦芽糖苷和5-硫代麦芽糖：由大肠杆菌麦芽糖转运系统转运的类似物。
Methyl-alpha-maltoside and 5-thiomaltose: analogs transported by the Escherichia coli maltose transport system.
作者信息
Ferenci T
出版信息
J Bacteriol. 1980 Oct;144(1):7-11. doi: 10.1128/jb.144.1.7-11.1980.
Abstract
Neither methyl-alpha-maltoside nor 5-thiomaltose is utilized by Escherichia coli as a sole carbon source. Both are, however, effective competitive inhibitors of maltose transport into the bacterium (Km for maltose, 0.8 microM, Ki for methyl-alpha-maltoside, 5.5 microM; Ki for 5-thiomaltose, 0.2 microM). Both analogs are bound by the periplasmic maltose-binding protein. Methyl-alpha-[14C]maltoside and 5-[3H]thiomaltose were both accumulated inside E. coli. Methyl-alpha-maltoside was unchanged after accumulation, but 5-thiomaltose was converted to an unidentified compound that could exit from the bacterium. Both analogs were inhibitory to the growth of E. coli, but only when the bacteria were previously induced for the maltose transport system. The analogs are substrates for but poor inducers of the maltose transport system.
摘要
甲基 -α-麦芽糖苷和5-硫代麦芽糖都不能被大肠杆菌用作唯一碳源。然而，它们都是麦芽糖转运进入细菌的有效竞争性抑制剂（麦芽糖的Km为0.8微摩尔，甲基 -α-麦芽糖苷的Ki为5.5微摩尔；5-硫代麦芽糖的Ki为0.2微摩尔）。这两种类似物都能与周质麦芽糖结合蛋白结合。甲基 -α-[14C]麦芽糖苷和5-[3H]硫代麦芽糖都能在大肠杆菌内积累。甲基 -α-麦芽糖苷积累后未发生变化，但5-硫代麦芽糖被转化为一种未知化合物，该化合物可从细菌中排出。这两种类似物都对大肠杆菌的生长有抑制作用，但只有在细菌先前被诱导产生麦芽糖转运系统时才会如此。这些类似物是麦芽糖转运系统的底物，但诱导能力较差。
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