El-Ghobarey A E, Sloane D J, Whaley K
Scott Med J. 1980 Oct;25(4):293-8. doi: 10.1177/003693308002500409.
During the two-year period (1st October 1974-30th September 1976), 2979 sera were tested for DNA antibodies by the Farr test. One thousand six hundred and ninety-five of these were tested because they had high ANA titres (1/256 or greater). In this group 285 sera were found to have raised DNA binding capacities (DNA-bc), 86 of which were found in patients having diagnoses other than SLE. When the diagnoses were reviewed following the finding of a raised DNA-bc, 55 of these patients were found to be suffering from SLE. Of the 1284 sera tested for DNA antibodies without the prior ANA screening procedures, 288 were positive, 36 of which came from patients not considered to have SLE; 30 of these patients were subsequently shown to have SLE. Thus the DNA-bc test is an important tool in the diagnosis of SLE, and the ANA test appears to be a valuable screening procedure. The level of DNA-bc was not of any diagnostic value.
在两年期间（1974年10月1日至1976年9月30日），采用Farr试验对2979份血清进行了DNA抗体检测。其中1695份血清因抗核抗体（ANA）滴度较高（1/256或更高）而接受检测。在这组血清中，发现285份血清的DNA结合能力（DNA-bc）升高，其中86份来自诊断为非系统性红斑狼疮（SLE）的患者。在发现DNA-bc升高后复查诊断时，发现这些患者中有55例患有SLE。在未经事先ANA筛查程序而检测DNA抗体的1284份血清中，288份呈阳性，其中36份来自未被认为患有SLE的患者；这些患者中有30例随后被证实患有SLE。因此，DNA-bc检测是SLE诊断的一项重要工具，而ANA检测似乎是一种有价值的筛查程序。DNA-bc水平没有任何诊断价值。
