Colburn K K, Wong L G, Ashman R F, Wistar R, Weisbart R H
Infect Immun. 1980 Dec;30(3):674-7. doi: 10.1128/iai.30.3.674-677.1980.
Staphylococcal protein A is a bacterial cell wall product that binds human immunoglobulin G and thereby interferes with opsonization and phagocytosis of Staphylococcus aureus by neutrophils. Phagocytic cells are also responsive to various non-immunoglobulin lymphocyte mediators. We utilized the detection of a newly recognized mediator, a neutrophil migration inhibition factor from T-lymphocytes (NIF-T), to show that aggregates of staphylococcal protein A and immunoglobulins G could inhibit the responsiveness of neutrophils to NIF-T. That such aggregates may alter the responsiveness of neutrophils to lymphocyte mediators that amplify or modulate phagocytic functions may have important pathogenetic implications in staphylococcal infection.
葡萄球菌蛋白A是一种细菌细胞壁产物，它能与人免疫球蛋白G结合，从而干扰中性粒细胞对金黄色葡萄球菌的调理作用和吞噬作用。吞噬细胞也对各种非免疫球蛋白淋巴细胞介质有反应。我们利用检测一种新发现的介质，即来自T淋巴细胞的中性粒细胞迁移抑制因子（NIF-T），来表明葡萄球菌蛋白A和免疫球蛋白G的聚集体可抑制中性粒细胞对NIF-T的反应性。这种聚集体可能改变中性粒细胞对放大或调节吞噬功能的淋巴细胞介质的反应性，这在葡萄球菌感染中可能具有重要的发病机制意义。
