Cranage M P, Gardner P S, McIntosh K
Clin Exp Immunol. 1981 Jan;43(1):28-35.
Respiratory syncytial (RS) virus causes a local infection of the respiratory tract which is frequently severe in infants. We report the development in infected infants of antibodies in respiratory secretions capable of mediating in vitro destruction of RS virus-infected tissue culture cells in conjunction with non-immune lymphoid cells. The cytotoxic antibody activity was not detectable in nasal secretions from infants hospitalized with respiratory infections where RS virus was not identified. The rise in activity occurred concurrently with recovery from infection and the rise in specific IgG, IgM and IgA antibody levels measured by membrane immunofluorescence assay, but was dissociated from the development of plaque-neutralizing activity. In serum it appears that the cytotoxic antibody belongs to the IgG class as shown by its ability to cross the placenta and by neutralization with specific antiserum. These findings are discussed in relationship to secretory antibody responses in RS virus infection with respect to pathogenesis and recovery.
呼吸道合胞（RS）病毒可引起呼吸道局部感染，这种感染在婴儿中常常较为严重。我们报告了受感染婴儿呼吸道分泌物中抗体的产生情况，这些抗体能够与非免疫性淋巴细胞共同介导体外对RS病毒感染的组织培养细胞的破坏。在因呼吸道感染住院但未检测到RS病毒的婴儿的鼻分泌物中未检测到细胞毒性抗体活性。活性的升高与感染恢复以及通过膜免疫荧光测定法测得的特异性IgG、IgM和IgA抗体水平的升高同时发生，但与噬斑中和活性的发展无关。在血清中，细胞毒性抗体似乎属于IgG类，这可通过其穿过胎盘的能力以及用特异性抗血清进行中和来证明。就发病机制和恢复而言，将结合RS病毒感染中的分泌性抗体反应对这些发现进行讨论。
