人类针对感染呼吸道合胞病毒的靶细胞的抗体依赖性细胞介导的细胞毒性作用。
Human antibody-dependent cell-mediated cytotoxicity against target cells infected with respiratory syncytial virus.
作者信息
Scott R, de Landazuri M O, Gardner P S, Owen J J
出版信息
Clin Exp Immunol. 1977 Apr;28(1):19-26.
Abstract
A chromium release assay was established to study human antibody-dependent cell-mediated cytotoxicity (ADCC) of HEp 2 cells infected with respiratory syncytial (RS) virus. Human peripheral blood lymphocytes in the presence of specific antibody to RS virus caused in vitro lysis of RS virus infected target cells. ADCC was detected in sera of infants with RS virus infections and in specimens of colostrum. The ability of serum or colostrum to mediate the cytotoxic reaction appeared to be related to the level of specific IgG, or IgA antibody to RS virus, as detected by membrane fluorescence. Separation of effector cells by their glass adherence properties showed that the ability to produce cytotoxicity resided in non-adherent effector cells.
摘要
建立了一种铬释放试验，以研究感染呼吸道合胞（RS）病毒的HEp 2细胞的人抗体依赖性细胞介导的细胞毒性（ADCC）。在存在针对RS病毒的特异性抗体的情况下，人外周血淋巴细胞在体外导致RS病毒感染的靶细胞裂解。在RS病毒感染婴儿的血清和初乳样本中检测到ADCC。血清或初乳介导细胞毒性反应的能力似乎与通过膜荧光检测到的针对RS病毒的特异性IgG或IgA抗体水平有关。根据效应细胞的玻璃黏附特性进行分离，结果显示产生细胞毒性的能力存在于非黏附性效应细胞中。
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