Hughes C, Phillips R, Roberts A P
Infect Immun. 1982 Jan;35(1):270-5. doi: 10.1128/iai.35.1.270-275.1982.
The sensitivity to normal human serum of 91 smooth strains of Escherichia coli isolated from urinary tract infections was determined. Production of hemolysin, which was common and associated primarily with the types O4, O6, O18, and O75, was significantly correlated with high levels of serum resistance, both within the total population and within individual O types. In contrast, serum resistance was not significantly associated with antibiotic resistance (whether transmissible or not), with colicinogeny in general, or with colicin V production in particular. This indicates that the carriage of R and ColV plasmids, shown previously to be capable of conferring increased levels of serum resistance on individual strains of E. coli isolated from other sources, does not play an important part in determining the serum sensitivity of the E. coli population involved in urinary tract infection.
测定了从尿路感染中分离出的91株光滑型大肠杆菌对正常人血清的敏感性。溶血素的产生较为常见，主要与O4、O6、O18和O75型相关，在总体人群以及各个O型内，溶血素的产生与高水平的血清抗性显著相关。相比之下，血清抗性与抗生素抗性（无论是否可传播）、一般的产大肠杆菌素能力，特别是产大肠杆菌素V之间均无显著关联。这表明，先前已证明能够使从其他来源分离出的个别大肠杆菌菌株的血清抗性水平增加的R质粒和ColV质粒的携带，在决定参与尿路感染的大肠杆菌群体的血清敏感性方面并不起重要作用。
