金刚烷胺、金刚乙胺和氯苯那敏对中枢神经系统副作用的双盲对照研究。
Double-blind controlled study of central nervous system side effects of amantadine, rimantadine, and chlorpheniramine.
作者信息
Millet V M, Dreisbach M, Bryson Y J
出版信息
Antimicrob Agents Chemother. 1982 Jan;21(1):1-4. doi: 10.1128/AAC.21.1.1.
Abstract
A total of 52 healthy, adult volunteers were randomly assigned to five treatment groups to be treated twice daily for 4 days with 100 mg of amantadine, 100 mg of rimantadine, 4 mg of chlorpheniramine or placebo alone, or 100 mg of amantadine in combination with chlorpheniramine. The results of tests measuring performance on tasks of attention, reasoning, and memory were unaffected by treatment. Subjective side effects in recipients of amantadine, rimantadine, and chlorpheniramine were comparable and minimal. Side effects appeared to be enhanced in subjects receiving both amantadine and chlorpheniramine.
摘要
总共52名健康成年志愿者被随机分为五个治疗组，分别接受以下治疗，每日两次，持续4天：单独服用100毫克金刚烷胺、100毫克金刚乙胺、4毫克氯苯那敏或安慰剂，或100毫克金刚烷胺与氯苯那敏联合服用。测量注意力、推理和记忆任务表现的测试结果不受治疗影响。金刚烷胺、金刚乙胺和氯苯那敏服用者的主观副作用相当且轻微。同时服用金刚烷胺和氯苯那敏的受试者副作用似乎有所增强。
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本文引用的文献
1
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J Infect Dis. 1980 May;141(5):543-7. doi: 10.1093/infdis/141.5.543.
2
Comparative toxicity of amantadine hydrochloride and rimantadine hydrochloride in healthy adults.盐酸金刚烷胺与盐酸金刚乙胺对健康成年人的毒性比较
Antimicrob Agents Chemother. 1981 Feb;19(2):226-33. doi: 10.1128/AAC.19.2.226.
3
Evaluation of amantadine in artificially induced A2 and B influenza.金刚烷胺在人工诱发甲型和乙型流感中的评估。
JAMA. 1970 Aug 31;213(9):1448-54.
4
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N Engl J Med. 1969 Sep 11;281(11):579-84. doi: 10.1056/NEJM196909112811102.
5
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6
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