Vatn M H, Stalsberg H
Cancer. 1982 Feb 15;49(4):819-25. doi: 10.1002/1097-0142(19820215)49:4<819::aid-cncr2820490435>3.0.co;2-d.
The colon and rectum were removed from 445 consecutive autopsies and examined for the presence of polypoid lesions under an illuminating magnifying lens. There were seven clinically undiagnosed carcinomas, 329 adenomas, 174 hyperplastic polyps, 59 mucosal tags, 34 other polypoid lesions, and 54 polyps in which no histologic diagnosis could be made. Adenomas were present in 34% of the men and 32% of the women. The adenoma prevalence rate increased smoothly with age in men, whereas the rate in women showed a biphasic variation with a peak at 50--59 years followed by a second increase after 70 years of age. The distribution of adenomas within the bowel showed a marked change with age, from a moderate left-sided predominance before 60 years of age to a marked right-sided predominance in patients over 80 years of age, particularly in men. Hyperplastic polyps were present in 27% of the men and 18% of the women. In men, their frequency and distribution within the bowel showed similar changes with age as were seen for the adenomas. In women, no such age-dependency was observed for hyperplastic polyps. Multiplicity of polyps increased with age and was more pronounced in men than in women. Adenomas in women tended to be larger, more atypical, and more villous than in men. A comparison with a similar study from Northern Norway showed no difference in the prevalence of adenomas in spite of a 70% higher incidence rate for colorectal cancer in Oslo.
从445例连续尸检中取出结肠和直肠，在照明放大镜下检查是否存在息肉样病变。有7例临床未诊断出的癌、329例腺瘤、174例增生性息肉、59例黏膜赘生物、34例其他息肉样病变以及54例无法做出组织学诊断的息肉。腺瘤在34%的男性和32%的女性中存在。男性腺瘤患病率随年龄平稳上升，而女性患病率呈双相变化，在50 - 59岁达到峰值，70岁以后再次上升。肠道内腺瘤的分布随年龄有显著变化，60岁以前以左侧中度占优，80岁以上患者尤其是男性则以右侧显著占优。增生性息肉在27%的男性和18%的女性中存在。在男性中，其在肠道内的频率和分布随年龄变化与腺瘤相似。在女性中，增生性息肉未观察到这种年龄依赖性。息肉的多发性随年龄增加，男性比女性更明显。女性的腺瘤往往比男性更大、更不典型且绒毛状更多。与挪威北部一项类似研究相比，尽管奥斯陆的结直肠癌发病率高70%，但腺瘤患病率并无差异。
