Johannsen L G, Momsen O, Jacobsen N O
University Institute of Pathology, Arhus Kommunehospital, Denmark.
Scand J Gastroenterol. 1989 Sep;24(7):799-806. doi: 10.3109/00365528909089217.
In 336 consecutive autopsies a total of 305 tumors were recorded in the large intestine. Of these, 184 were adenomas occurring in 26% of the 196 men and 17% of the 140 women, resulting in an overall prevalence of 22%, or 15% when standardized to the world standard population (WSP). The prevalence of adenomas increased with age, and a shift from distal to proximal location occurred in the older age groups, mostly accounted for by the greater tendency to multiplicity in old age. Regardless of age 57% of the cases of adenomas could have been identified by flexible sigmoidoscopy. The prevalence of hyperplastic polyps was 13%, and an association between these and adenomas was found. Five adenocarcinomas occurred in the study. With some exceptions, which are discussed in detail, the results are in accordance with studies from other countries with a high incidence of colorectal cancer and similar socioeconomic composition. The study supports the theory of the adenoma-carcinoma sequence.
在336例连续尸检中，共记录到大肠肿瘤305个。其中，184个为腺瘤，在196名男性中发生率为26%，在140名女性中发生率为17%，总体患病率为22%，按照世界标准人口（WSP）标准化后为15%。腺瘤患病率随年龄增长而增加，在老年组中出现从远端向近端位置的转移，这主要是由于老年时多发倾向更大。无论年龄大小，57%的腺瘤病例可通过乙状结肠镜检查发现。增生性息肉的患病率为13%，且发现这些息肉与腺瘤之间存在关联。本研究中有5例腺癌。除了一些将详细讨论的例外情况，研究结果与其他结直肠癌高发且社会经济构成相似的国家的研究结果一致。该研究支持腺瘤-癌序列理论。
