Madsen H, Kjaergaard J J, Ditzel J
Diabetologia. 1982 Jan;22(1):37-40. doi: 10.1007/BF00253867.
The relationship between blood glucose and glycosylated haemoglobin (HbAlc) had been investigated during an 8 week period in 53 Type 1 (insulin-dependent) diabetic women studied during the third trimester of pregnancy. Blood glucose estimations (fasting and 2h post-prandially) were made an average of 41 times in each patient during this period and HbAlc was determined once at the end of the study. There was a significant correlation between both the mean blood glucose over the preceding 8 weeks and the standard deviation of the fasting blood glucose with HbAlc (r = 0.69, p less than 0.001; r = 0.46, p less than 0.001, respectively). A "glycosylation index" was calculated for each patient (HbAlc divided by the mean blood glucose value). There was a significant correlation between the "glycosylation index" and duration of diabetes (r = 0.68, p less than 0.001). In contrast, there was no correlation between red cell 2,3-diphosphoglycerate and HbAlc or "glycosylation index". These findings suggest that increasing duration of diabetes influences the post-translational formation of HbAlc and that isolated HbAlc values need to be interpreted with caution in the pregnant diabetic.
在53名妊娠晚期的1型（胰岛素依赖型）糖尿病女性中，对血糖与糖化血红蛋白（HbAlc）之间的关系进行了为期8周的研究。在此期间，每位患者平均进行了41次血糖测定（空腹及餐后2小时），并在研究结束时测定了一次HbAlc。前8周的平均血糖以及空腹血糖标准差与HbAlc之间均存在显著相关性（分别为r = 0.69，p < 0.001；r = 0.46，p < 0.001）。为每位患者计算了一个“糖化指数”（HbAlc除以平均血糖值）。“糖化指数”与糖尿病病程之间存在显著相关性（r = 0.68，p < 0.001）。相比之下，红细胞2,3 - 二磷酸甘油酸与HbAlc或“糖化指数”之间无相关性。这些发现表明，糖尿病病程的延长会影响HbAlc的翻译后形成，并且在妊娠糖尿病患者中，单独的HbAlc值需要谨慎解读。
