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抗乙酰胆碱受体抗体:与重症肌无力诊断及临床情况的相关性

Anti AChR antibody: relevance to diagnosis and clinical aspects of myasthenia gravis.

作者信息

Mantegazza R, Pareyson D, Baggi F, Romagnoli P, Peluchetti D, Sghirlanzoni A, Cornelio F

机构信息

Servizio di Studio e Cura delle Malattie Neuromuscolari, Istituto Neurologico C. Besta, Milano.

出版信息

Ital J Neurol Sci. 1988 Apr;9(2):141-5. doi: 10.1007/BF02337460.

Abstract

227 sera from myasthenic patients were tested for the presence of anti-AChR antibodies (anti-AChR Abs) by mean of a fetal calf receptor (Fc-AChR); 73.5% of cases proved positive with this method. Significant correlations were found between presence of anti-Fc-AChr Abs and various clinical aspects such as: clinical stage and duration of disease; moreover significantly higher than the median titers were found among younger patients (i.e. age less than 40 yrs).

摘要

采用胎牛受体(Fc-AChR)检测了227份重症肌无力患者血清中抗乙酰胆碱受体抗体(抗AChR抗体)的存在情况;73.5%的病例经此方法检测呈阳性。抗Fc-AChR抗体的存在与各种临床情况之间存在显著相关性,如临床分期和病程;此外,在年轻患者(即年龄小于40岁)中发现滴度显著高于中位数。

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