Jacquemier J D, Rolland P H, Vague D, Lieutaud R, Spitalier J M, Martin P M
Cancer. 1982 Jun 15;49(12):2534-6. doi: 10.1002/1097-0142(19820615)49:12<2534::aid-cncr2820491221>3.0.co;2-j.
Tissue specimens from 27 patients with mammary fibrocystic disease were assayed for estrogen (ER) and progestin (PR) receptors. Seventeen patients (63%) had ER-positive lesions (greater than 5 fmol/mg protein). A progression in ER presence was noted from fibrocystic disease (35%) and fibrosing adenosis (50%) to lobular and ductal hyperplasia (85%). Similarly, ER content increased from 14.5 +/- 13 fmol/mg cytosol protein in fibrocystic disease and fibrosing adenosis to 31.5 +/- 23 fmol/mg protein in epithelial hyperplastic lesions. Furthermore, the ER-PR couple was only encountered in lobular and ductal hyperplasia. The authors' data indicate that the incidence of steroid receptor parallels the intensity of hyperplasia in benign breast disease.
对27例乳腺纤维囊性疾病患者的组织标本进行雌激素（ER）和孕激素（PR）受体检测。17例患者（63%）的病变为ER阳性（大于5 fmol/mg蛋白）。从纤维囊性疾病（35%）、纤维性腺病（50%）到小叶和导管增生（85%），可观察到ER存在情况呈进展性变化。同样，ER含量从纤维囊性疾病和纤维性腺病中的14.5±13 fmol/mg胞浆蛋白增加到上皮增生性病变中的31.5±23 fmol/mg蛋白。此外，仅在小叶和导管增生中发现ER-PR偶联。作者的数据表明，类固醇受体的发生率与良性乳腺疾病中增生的强度平行。
