卡德古霉素，一种新型核苷类似物抗生素。I. 卡德古霉素的产生菌、生产与分离。

Cadeguomycin, a noval nucleoside analog antibiotic. I. The producing organism, production and isolation of cadeguomycin.

作者信息

Tanaka N, Wu R T, Okabe T, Yamashita H, Shimazu A, Nishimura T

出版信息

J Antibiot (Tokyo). 1982 Mar;35(3):272-8. doi: 10.7164/antibiotics.35.272.

DOI:10.7164/antibiotics.35.272

Abstract

An actinomycete strain IM7912T was found to produce cadeguomycin, a new nucleoside analog antibiotic, together with tubercidin. Morphological, cultural and physiological studies showed that the organism belongs to the species Streptomyces hygroscopicus. Comparisons with S. hygroscopicus ISP 5578 revealed that both strains possess similar characteristics except for production of yellow or brownish yellow soluble pigment in some media. Cadeguomycin was isolated from the culture filtrate, separated from tubercidin, and purified.

摘要

发现一株放线菌IM7912T可产生一种新的核苷类似物抗生素cadeguomycin以及杀结核菌素。形态学、培养和生理学研究表明，该菌株属于吸水链霉菌。与吸水链霉菌ISP 5578的比较显示，除了在某些培养基中产生黄色或棕黄色可溶性色素外，两株菌具有相似的特征。从培养滤液中分离出cadeguomycin，与杀结核菌素分离并纯化。