Garcia Leme J, Ramos de Oliveira J C, Sudo L S, Veríssimo de Mello S B
Br J Exp Pathol. 1978 Aug;59(4):345-53.
Intravenous administration to leucopenic rats of lymphocyte suspensions, or lymphocyte products, restored the depressed inflammatory responses of these animals to various inflammatory stimuli. Utilizing carrageenin to induce inflammatory responses in leucopenic animals, an enhanced restorative effect of lymphocytes, or of their products, was observed when the cells were collected from donor rats in which a persistent inflammatory lesion was previously induced in the paw by the local injection of complete Freund's adjuvant (CFA). The enhancement of cell activity was gradual with the age of the lesion: cells collected from donors bearing 3-day-old lesions were less effective than cells from donors in which the persistent inflammatory lesion was induced 18 days before. Steroidal and non-steroidal anti-inflammatory drugs (e.g. hydrocortisone, aspirin, sodium salicylate and indomethacin), administered to donor animals, were capable of blocking the restorative effect of lymphocytes. This blocking action affected also cells rendered hyperactive by the stimulus of CFA-induced lesions, but was reverted by the interruption of drug administration to donors. When cells rendered inactive by the action of anti-inflammatory drugs were disrupted before injection into leucopenic animals, the resulting cell products were capable of restoring the depressed inflammatory responses of these animals to carrageenin. Aspirin was an exception, because it rendered inactive the cell products besides the intact cells. It is concluded that persistent inflammatory responses induced by CFA enhance the proinflammatory function of lymphocytes in the rat which, in turn, might contribute to the persistency of the response. Antiinflammatory drugs may interrupt this sort of vicious circle by decreasing the amounts of the available active cell products.
给白细胞减少的大鼠静脉注射淋巴细胞悬液或淋巴细胞产物，可恢复这些动物对各种炎症刺激的减弱的炎症反应。利用角叉菜胶在白细胞减少的动物中诱导炎症反应，当从供体大鼠收集细胞时，观察到淋巴细胞或其产物具有增强的恢复作用，在这些供体大鼠中，先前通过局部注射完全弗氏佐剂（CFA）在爪部诱导了持续性炎症病变。细胞活性的增强随着病变年龄的增长而逐渐增加：从患有3日龄病变的供体收集的细胞比从18天前诱导持续性炎症病变的供体收集的细胞效果差。给供体动物施用甾体和非甾体抗炎药（例如氢化可的松、阿司匹林、水杨酸钠和吲哚美辛）能够阻断淋巴细胞的恢复作用。这种阻断作用也影响因CFA诱导的病变刺激而变得活跃的细胞，但通过中断对供体给药而恢复。当被抗炎药作用而失活的细胞在注入白细胞减少的动物之前被破坏时，产生的细胞产物能够恢复这些动物对角叉菜胶减弱的炎症反应。阿司匹林是个例外，因为它除了使完整细胞失活外，还使细胞产物失活。结论是，CFA诱导的持续性炎症反应增强了大鼠淋巴细胞的促炎功能，这反过来可能有助于反应的持续性。抗炎药可能通过减少可用活性细胞产物的量来中断这种恶性循环。
