Korte C, Jalal S M
J Hered. 1982 May-Jun;73(3):224-6. doi: 10.1093/oxfordjournals.jhered.a109622.
Potential for genetic damage in future generations from such widely used hormonic herbicide as 2,4-D (2,4-dichlorophenoxyacetic acid) is of serious concern. Yet the data, particularly on mammalian systems, continue to be inadequate and inconclusive. An attempt was made in this study to determine the clastogenic and mutagenic potential of 2,4-D in cultured lymphocytes. Chromosome damage though statistically insignificant occurred at dosages as low as 0.2 microgram/ml. Chromosome damage was increased at a statistically significant level whenever the concentration was 50 microgram/ml or higher. Mutagenicity, based on rates of increase in sister chromatid exchanges, was significant at 10 micrograms/ml of higher concentrations. Statistical testing was based o analysis of variance, Dunnett's multiple comparison tests and linear regressions. It seems imperative therefore to avoid indiscriminate use of 2,4-D, and to test the compound for long-range low-level exposures.
像2,4-二氯苯氧乙酸（2,4-D）这种广泛使用的激素类除草剂对后代造成基因损伤的可能性令人严重担忧。然而，相关数据，尤其是关于哺乳动物系统的数据，仍然不充分且没有定论。本研究试图确定2,4-D在培养淋巴细胞中的致断裂和致突变潜力。尽管从统计学上看并不显著，但在低至0.2微克/毫升的剂量下就出现了染色体损伤。每当浓度达到50微克/毫升或更高时，染色体损伤就会在统计学上显著增加。基于姐妹染色单体交换增加率的致突变性在10微克/毫升及更高浓度时显著。统计检验基于方差分析、邓尼特多重比较检验和线性回归。因此，避免滥用2,4-D并对该化合物进行长期低水平暴露测试似乎势在必行。
