Weathersbee P S, Olsen L K, Lodge J R
Postgrad Med. 1977 Sep;62(3):64-9. doi: 10.1080/00325481.1977.11714605.
A population group consisting of 800 households of women who recently had been pregnant was surveyed to determine the level of consumption of a variety of beverages. Three fourths of the subjects were Mormon. Of a subgroup of 16 women identified as having an estimated daily intake of caffeine of 600 mg or greater, 13 had experienced a reproductive loss in the form of spontaneous abortion (eight) or stillbirth (five), two had given birth to premature infants, and only one had had an uncomplicated delivery. An inordinately high rate or reproductive loss also was noted in 13 households where the man's estimated daily intake of caffeine was greater than 600 mg. A cause-and-effect relationship cannot be determined by this type of retrospective study, but physicians should keep in mind the possibility that an excessive intake of caffeine may be a factor in otherwise unexplainable spontaneous abortion or perinatal mortality.
对一个由800户近期怀孕的女性家庭组成的群体进行了调查，以确定各种饮料的消费水平。四分之三的受试者是摩门教徒。在一个由16名女性组成的亚组中，估计她们每日咖啡因摄入量为600毫克或更高，其中13人经历了自然流产（8例）或死产（5例）形式的生殖损失，2人生下了早产儿，只有1人分娩顺利。在13个家庭中，男性估计每日咖啡因摄入量大于600毫克，生殖损失率也异常高。这种回顾性研究无法确定因果关系，但医生应记住，过量摄入咖啡因可能是导致不明原因自然流产或围产期死亡的一个因素。
